Research Achievements
1
REF2021: Anti–Müllerian hormone (AMH): from novel antibodies to routine clinical immunoassay tools in worldwide use
REF2021: Second-generation Inhibin B biomarker assay: impact on male fertility testing and diagnosis and monitoring remission of ovarian granulosa cell cancer
2
Developed the first clinical research immunoassays for inhibin A, inhibin B, inhibin pro alpha c, activin A. The key assays are widely used commercially and provided the technology behind Brookes University’s first spin-out company Oxford Bio-Innovation.
https://emeritusprofessorgroome.uk/wp/wp-content/uploads/2016/04/OBI.pdf
This was sold to a US diagnostic company in 2001 for around £1 million.
3
I am coauthor on 320 refereed scientific publications listed in the web of science database. For publications in the period 1993-2003 I was in the highest 0.1% for cited authors in clinical medicine. In 2009 a published analysis of European authors in the field Reproductive Biomedicine placed me 4th out of all authors for citations to published work and I had the second most cited paper overall (First inhibin B assay). Almost all of these papers used as key reagents the novel antibodies from our laboratory at Oxford Brookes University.
https://emeritusprofessorgroome.uk/wp/reproductive-biomedicine/
4
Google scholar shows that over my career as of 2024 – 88 of my papers have been cited over 100 times and my total h index is 94.
https://scholar.google.co.uk/citations?user=ARgk6zwAAAAJ&hl=en
These photographs are of the most cited european authors in reproductive medicine of the period 1993-2003.
John Sumpter (1.)
Niels Skakkebaek (2.)
A. van Steirteghem (3.)
Nigel Groome (4.)
Eberhard Nieschlag (5.)
Carlos Simón (12.)
Philippa Saunders (18.)
Outi Hovatta (23.)
5
https://scholar.google.co.uk/citations?user=ARgk6zwAAAAJ&hl=en
The h statistic based on citation data is an indicator of the impact of a scientists work on the field and related fields.
For NP Groome h= 94
This article helps to understand what is a good H-index for a Professor in the life sciences.
6
Successful licensing of many antibodies and assays with total royalty income to Brookes around 3 million UK pounds in 2017. Royalty income has increased steadily year on year since 1996 when the first inhibin assay was sold.
7
Widely recognised as responsible for major developments in the understanding of aspects of human reproduction relevant to inhibin. A and B.
8
Assays from our laboratory provide routine tools for prenatal screening and infertility investigations in laboratories worldwide. 70% of pregnancies in the US are screened using the quad or integrated tests which use inhibin A. In 2011 the US College of Pathologists Report showed that over 3 million inhibin A tests were done in the US.
9
Two granted US patents on clinical applications of inhibin A assay, one on AMH and one on activin C.
10
Developed the monoclonal antibody pair used in the manual Beckman Gen II AMH assay and the Beckman and Roche fully automated AMH assays. AMH has many clinical application including assesment of female fertility and ovarian reserve (how many eggs remain).
11
Productive collaborations resulting in coauthored papers with research groups in Japan, the USA, Finland, New Zealand, Austria, Denmark, the Netherlands, France, Australia, Argentina and other countries.
12
Successful supervision of many Brookes University PhD students including – Janice Harland, Adrian Dawkes, Richard Barry, Terry Woolley, Jean Walters, Lee Evans, Michelle Yon, Mark Cranfield, Mohammed Meerasahib, Ahmed al-Qahtani., Matthew Hazell and Helen Ludlow.
Cosupervision of two PhD students from the John Radcliffe hospital in Oxford – Mike Bunce and Craig Taylor.
13
In the 2014 REF national research assessment exercise for UK Universities Brookes University included, amongst others, an impact case study based on the inhibin work. The inhibin case study was generally agreed to be one of, if not the strongest impact studies submitted by Brookes.
https://emeritusprofessorgroome.uk/wp/wp-content/uploads/2016/05/REFWORD2.pdf
The University gained more research funds than ever before.
14
Earnings from the intellectual property of UK Universities
This is the official league table for the 2022/23 academic year.
You will see that many Universities report almost no earnings from IP, and Brookes is ahead of some very prestigious colleges eg the University of Edinburgh and Kings college London, and only slightly below Imperial College London. These have many more resources for research.
Brookes has been in the top ten for some time and is now in 9th position just ahead of Edinburgh University. At the time of writing we await the 2023/24 figures which should show a further increase in income from IP for Oxford Brookes University.
Brookes is, of course, way ahead of all the former polytechnics and most of the Russell group of elite research universities.
The list of the top 9 Universities in the league table of earnings from IP and inventions are shown below.
2022-2023
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Oxford University – £83,944,00
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University of Sheffield – £55,472,000
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Cambridge University – £25,774,000
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Institute of Cancer Research – £18,640,000
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Queens University Belfast – £11,161,000
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University College London – £10,015,000
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University of Southampton – £9,177,000
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Imperial College London – £7,712,000
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Oxford Brookes University – £6,384,000
15
Brookes University has chosen for many years to use some of the royalty income to fund 3 year PhD students in the health and life sciences area. Each year all the current postgraduates participate in a symposium where some students do oral or poster presentations and are judged and the best are awarded prizes. The studentships are called Professor Nigel Groome PhD studentships. At the symposium held in the John Henry Brookes lecture theatre on 13th January 2016 there were 30 attending students funded from the royalty income. The following photograph was taken of these students and myself.
The best student receives a certificate and various cash prizes. The prizes are sponsored by a company and are known as Professor Nigel Groome prizes.
The following photograph shows one of the prizewinners in 2016. On the left is Professor Linde King.
RECENT RECIPIENTS OF NIGEL GROOME STUDENTSHIPS
1. SAMUEL BURDEN
Associations of Global Country Profiles and Modifiable Risk Factors with COVID-19 Cases and Deaths | medRxiv.
https://www.medrxiv.org/content/10.1101/2020.06.17.20133454v1
https://www.medrxiv.org/content/10.1101/2020.06.17.20133454v1.full
https://www.medrxiv.org/content/10.1101/2020.06.17.20133454v1.full.pdf
Intensity and Duration of Physical Activity and Cardiorespiratory Fitness.
2. TOM CHAPMAN
Blunted perception of breathlessness in three cases of low grade insular-glioma.
https://pubmed.ncbi.nlm.nih.gov/38410161/
3. JESSICA CHAVAZ
Impact of Cropland Management on Invertebrate Richness and Abundance in Agroforestry Systems in Bali, Indonesia.
https://ouci.dntb.gov.ua/works/40ZykGm9/
4. EMMA DAVIES
The effect of alcohol strength on alcohol consumption: findings from a randomised controlled cross-over pilot trial — Kings College.
https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-021-00777-4
5. MONICA DUMAN
Mapping local policy approaches to child neglect assessment practice and use of tools in England – Duman – 2024 – Child Abuse Review – Wiley Online Library.
https://onlinelibrary.wiley.com/doi/full/10.1002/car.2842
6. MOLLY HAIR
Whole cell reconstructions of Leishmania mexicana through the cell cycle.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012054
7. SHELLY HARRIS
Hormonal control of cell proliferation in fetal ovine pancreatic islets
https://www.endocrine-abstracts.org/ea/0038/ea0038p140
8. ALEYNA KARAGLU
With a background in veterinary medicine and previous research experience on tick-borne parasites, I’m currently pursuing my PhD at Oxford Brookes University, ResearchGate https://search.app/CEn7yJB3M3zkAB7UA
9. DANIEL LEITE
1. The Wnt and Delta-Notch signalling pathways interact to direct pair-rule gene expression via caudal during segment addition in the spider Parasteatoda tepidariorum | Development | The Company of Biologists
2. Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum | Genome Biology and Evolution | Oxford Academic
https://academic.oup.com/gbe/article/8/7/2133/2466064
3. An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis
https://ouci.dntb.gov.ua/en/works/7PPb2Yx7/
10. CATHERINE LOWENHOFF
Moving on from ‘Listening Visits’: a mixed methods, multi-phase study exploring the support that health visitors provide to mothers with mental health problems | Catherine Lowenhoff
11. LAURA MULCAHY
The effect of stressed cell-derived exosomes on metastating activity of ovarian and breast cancer cell lines in vitro.
https://search.app/TV3dhspqfuRuEXoE7
12. JESSICA PEIXINHO
The effects of prenatal smoke exposure on language development- a systematic review. Infant and child development. e2331. ISSN 1522-7227cd
https://doi.org/10.1002/icd.2331
13. YANICA SAID
A novel algorithm to calculate elementary modes: Analysis of Campylobacter jejuni metabolism
14. ANESH SENAN
Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. – Abstract – Europe PMC.
Structure, 2015 vol. 23(10) pp. 1889-1899.
Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
Beale, JH; Parker, JL; Samsudin, F; Barrett, AL; Senan, A; Bird, LE; Scott, D; Owens, RJ; Sansom, MSP; Tucker, SJ; Meredith, D; Fowler, PW; Newstead, S.
Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the POT family of proton-coupled oligopeptide transporters. PepT1 and PepT2 also play an important role in drug transport in the human body. Recent crystal structures of bacterial homologs revealed a conserved peptide-binding site and mechanism of transport. However, a key structural difference exists between bacterial and mammalian homologs with only the latter containing a large extracellular domain, the function of which is currently unknown. Here, we present the crystal structure of the extracellular domain from both PepT1 and PepT2 that reveal two immunoglobulin-like folds connected in tandem, providing structural insight into mammalian peptide transport. Functional and biophysical studies demonstrate that these domains interact with the intestinal protease trypsin, suggesting a role in clustering proteolytic activity to the site of peptide transport in eukaryotic cells.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
https://europepmc.org/article/med/26320580
15. FRANCES TOLMIE
Across the great divide: the plant cell surface continuum – ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S1369526614001563
The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsis. – Abstract – Europe PMC
https://europepmc.org/article/med/31182605
16. STEFAN WOJCIK
Beyond membrane curvature; Clade 6 reticulons and their role within the plant endoplasmic reticulum.
17. TOM CHAPMAN
Blunted perception of breathlessness in three cases of low grade insular-glioma.
https://pubmed.ncbi.nlm.nih.gov/38410161/
NIGEL GROOME STUDENTSHIPS ADVERTISED IN 2024
1. Understanding the function of NFXL1: a transcription factor implicated in speech and language development.
https://search.app/3mbAFEDyov187EwJ6
2. Early Language Development in Bilingual Infants.
https://www.jobs.ac.uk/job/share?job_ref=DEU104
3. Alcohol Consumption in Mid-life Women: Intervention Co-production and Evaluation.
https://www.jobs.ac.uk/job/share?job_ref=
4. Developing and Testing Tools to Determine the Protection Provided to Invertebrates by Agricultural Field Margins.
5. Nigel Groome Studentship: Wellbeing in Adults with Developmental Coordination Disorder (DCD) / Dyspraxia; The Role of Alcohol Consumption , Oxford Brookes University, United Kingdom.